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Rilematovir

CAS No. 1383450-81-4

Rilematovir ( JNJ-678 | JNJ-53718678 )

产品货号. M26723 CAS No. 1383450-81-4

JNJ-678是一种新型融合蛋白抑制剂。 JNJ-678 显示出治疗呼吸道合胞病毒 (RSV) 的潜力。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3483 有现货
10MG ¥5788 有现货
25MG ¥11550 有现货
50MG ¥16151 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Rilematovir
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    JNJ-678是一种新型融合蛋白抑制剂。 JNJ-678 显示出治疗呼吸道合胞病毒 (RSV) 的潜力。
  • 产品描述
    JNJ-678 is a novel inhibitor of the fusion protein. JNJ-678 shows the potential for respiratory syncytial virus (RSV) treatment.(In Vitro):Rilematovir is highly active against a number of RSV strains from both A and B subtypes, especially the A2 strain. The EC50 of HeLa cells is 460?pM.(In Vivo):Rilematovir efficiently suppresses established acute lower respiratory tract infection in the animals after oral treatment of neonatal lambs with Rilematovir, or with an equally active close analog.
  • 体外实验
    Rilematovir is a small-molecule respiratory syncytial virus (RSV) fusion inhibitor currently under clinical evaluation in infants hospitalized for RSV infection. Rilematovir binds to RSV F protein in its prefusion conformation. Rilematovir displays very potent antiviral activity and low cytotoxicity. In addition to its activity against the RSV A2 strain, Rilematovir is also highly active against a number of RSV strains from both A and B subtypes. The EC50 in an RSV infection assay using HeLa cells is 460?pM.
  • 体内实验
    Oral treatment of neonatal lambs with Rilematovir, or with an equally active close analog, efficiently inhibits established acute lower respiratory tract infection in the animals, even when treatment is delayed until external signs of respiratory syncytial virus illness have become visible.
  • 同义词
    JNJ-678 | JNJ-53718678
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1383450-81-4
  • 分子量
    500.92
  • 分子式
    C21H20ClF3N4O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 65 mg/mL (129.76 mM)
  • SMILES
    CS(=O)(=O)CCCn1c(Cn2c3cnccc3n(CC(F)(F)F)c2=O)cc2cc(Cl)ccc12
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Azevedo RDS, et al. Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase. Chemosphere. 2021 Jan;263:128029.
产品手册
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