Resorcinolnaphthalein

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Resorcinolnathaein 是血管紧张素转换酶 2 (ACE2) 的特异性增强剂（EC50 值为 19.5 μM）。间苯二酚萘 (100 μM) 和 XNT（EC50 值分别为 19.5 μM 和 20.1 μM）以剂量依赖性方式增强 ACE2 活性。

Resorcinolnaphthalein is a specific?enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM). ACE2 activity in a dose-dependent manner enhanced by Resorcinolnaphthalein (100 μM) and XNT (EC50 values of 19.5 μM and 20.1 μM, respectively).ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology.resorcinolnaphthalein enhanced ACE2 activity in a dose-dependent manner.?Acute in vivo administration of the xanthenone resulted in a dose-dependent transient and robust decrease in blood pressure (at 10 mg/kg, spontaneously hypertensive rats decreased 71+/-9 mm Hg and Wistar-Kyoto rats decreased 21+/-8 mm Hg;?P<0.05).?Chronic infusion of the xanthenone (120 microg/day) resulted in a modest decrease in the spontaneously hypertensive rat blood pressure (17 mm Hg;?2-way ANOVA;?P<0.05), whereas it had no effect in Wistar-Kyoto rats.?Strikingly, the decrease in blood pressure was also associated with improvements in cardiac function and reversal of myocardial, perivascular, and renal fibrosis in the spontaneously hypertensive rats.

Resorcinolnaphthalein (100 μM) andXNT enhances ACE2 activity in a dose-dependent manner with EC50 values of 19.5 μM and 20.1 μM, respectively.ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology.

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Endocrinology/Hormones

RAAS

ACE2

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41307-63-5

382.36

C24H14O5

>98% (HPLC)

DMSO : 120 mg/mL?(313.84 mM;?Need ultrasonic)

Oc1ccc2c(Oc3cc(O)ccc3C22OC(=O)c3cccc4cccc2c34)c1

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(-20℃)

With Ice Pack

≥ 2 years