RepSox ( E-616452 | SJN 2511 | E616452 | SJN2511 | E 616452 | SJN-2511 )

产品货号. M14530 CAS No. 446859-33-2

RepSox (E-616452, SJN-2511) 是一种有效的选择性 TGF-β I 型受体 ALK5 抑制剂，Ki 为 25 nM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥308	有现货
5MG	￥494	有现货
10MG	￥624	有现货
25MG	￥1288	有现货
100MG	￥3969	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

RepSox
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RepSox (E-616452, SJN-2511) 是一种有效的选择性 TGF-β I 型受体 ALK5 抑制剂，Ki 为 25 nM。
产品描述

RepSox (E-616452, SJN-2511) is a potent, selective inhibitor of TGF-β type I receptor ALK5 with Ki of 25 nM, inhibits ALK5 autophosphorylation with IC50 of 4 nM, can replace the central reprogramming factor Sox2 by inducing nanog; specifically acts by inhibiting Tgf-β signaling, does not act by inducing Sox2 expression in the target fibroblasts; efficiently replaces transgenic Sox2 in the absence of VPA and c-Myc, as well as in both embryonic and adult fibroblasts; demonstrates effectivity at generating iPSCs.
体外实验

RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs).RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs.RepSox (GMP) together with Forskolin (HY-15371) increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation.
体内实验

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同义词

E-616452 | SJN 2511 | E616452 | SJN2511 | E 616452 | SJN-2511
通路

TGF-beta/Smad
靶点

TGFBR
受体

ALK5|TGFβR1
研究领域

Cancer
适应症

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化学信息

CAS Number

446859-33-2
分子量

287.3186
分子式

C17H13N5
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 52 mg/mL
SMILES

CC1=CC=CC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=N1
化学全称

2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Ichida JK, et al. Cell Stem Cell. 2009 Nov 6;5(5):491-503. 2. Liu X, et al. Nat Cell Biol. 2013 Jul;15(7):829-38. 3. Gellibert F, et al. J Med Chem. 2004 Aug 26;47(18):4494-506. 4. Wu MZ, et al. Cell Res. 2014 Jun;24(6):641-2.

计算器

浓度计算器

摩尔计算器

分子量计算器

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