Razuprotafib ( AKB-9778 )

产品货号. M21740 CAS No. 1008510-37-9

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Razuprotafib
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM.
产品描述

Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM).
同义词

AKB-9778
通路

Metabolic Enzyme/Protease
靶点

Phosphatase
受体

——
研究领域

——
适应症

——

CAS Number

1008510-37-9
分子量

586.7
分子式

C26H26N4O6S3
纯度

>98% (HPLC)
溶解度

DMSO : 100 mg/mL (170.44 mM; Need ultrasonic)
SMILES

O=C([C@@H](NC(OC)=O)CC1=CC=CC=C1)N[C@H](C2=CSC(C3=CC=CS3)=N2)CC4=CC=C(NS(=O)(O)=O)C=C4
化学全称

——

1. Shen J, et al. Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. J Clin Invest. 2014;124(10):4564-4576.

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