Rabeprazole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Rabeprazole (LY307640) 是一种二代质子泵抑制剂 (pump inhibitor, PPI)，不可逆地抑制胃 H+/K+-ATPase。Rabeprazole 诱导细胞凋亡 (apoptosis)。Rabeprazole 也抑制尿苷核苷核糖水解酶 (UNH) ，IC50 为 0.3 μM。Rabeprazole 可用于胃溃疡和胃食管反流的研究。

Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux.

Rabeprazole attenuates the cell viability of the human gastric cancer cells following treatment with 0.2 mM for 16 hours.Rabeprazole completely inhibits the phosphorylation of ERK1/2 in the MKN-28 cells. The gastric cancer cell line MKN-28 is cultured in acidic culture media (pH 5.4) for 2 hours. Pretreatment with Rabeprazole (0.2 mM for 2 hours) leads to strong inhibition of ERK1/2 phosphorylation in the MKN-28 cells.Cell Viability Assay Cell Line:Three gastric cancer cell lines KATO III, MKN-28 and MKN-45 Concentration:0.2 mM Incubation Time:16 hours Result:Treatment resulted in the attenuation of viability in all cancer cell lines tested, the cell viability of the MKN-28 cells significantly decreased compared with the KATO III and MKN-45 cells, respectively. Cell Viability Assay Cell Line:Three gastric cancer cell lines (KATO III, MKN-28 and MKN-45) Concentration: 0.2 mM Incubation Time:Pretreatment for 2 hours Result:Led to strong inhibition of ERK 1/2 phosphorylation in the MKN-28 cells, but a similar effect was not observed in the KATO III and MKN-45 cells.

Rabeprazole (10 mg/kg; P.O.; every 48 h for 18 weeks) course leads to a significant decline in bone mineral density (BMD) and decreases serum calcium level and produces secondary hyperparathyroidism in female mice.Animal Model:Female Swiss albino mice (body weight equals 18-26 g) Dosage:10 mg/kg Administration:Oral administration; every 48 h for 18 weeks Result:Showed significantly lower serum calcium level compared to the vehicle treated group (5.5±2.07 vs. 9.68±2.77).

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Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel | STAT

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117976-89-3

359.44

C18H21N3O3S

>98% (HPLC)

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COCCCOc1ccnc(CS(=O)c2nc3ccccc3[nH]2)c1C

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(-20℃)

With Ice Pack

≥ 2 years