RTS-V5 ( Dual HDAC-proteasome inhibitor RTS-V5 )

产品货号. M13629 CAS No. 2285346-31-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RTS-V5
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor.
产品描述

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor with IC50 of 0.27 uM (HDAC6), inhibits HDAC8 (IC50=0.53 uM), and low activity against HDAC/1/2/3; demonstrates cytotoxicity against leukemia and multiple myeloma cell lines as well as therapy-refractory primary patient-derived leukemia cells.
同义词

Dual HDAC-proteasome inhibitor RTS-V5
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC
研究领域

——
适应症

——

CAS Number

2285346-31-6
分子量

525.61
分子式

C27H35N5O6
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(N[C@@H](CC(NCC(C)(C)C)=O)C(N[C@@H](C)C(NCC1=CC=CC=C1)=O)=O)C2=CC=C(C(NO)=O)C=C2
化学全称

N1-((S)-1-(((S)-1-(Benzylamino)-1-oxopropan-2-yl)amino)-4-(neopentylamino)-1,4- dioxobutan-2-yl)-N4 -hydroxyterephthalamide

1. Bhatia S, et al. J Med Chem. 2018 Oct 26. doi: 10.1021/acs.jmedchem.8b01487.

计算器

产品手册

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