RS-127445
CAS No. 199864-87-4
RS-127445 ( RS-127445; RS127445; MT-500 )
产品货号. M17415 CAS No. 199864-87-4
RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥324 | 有现货 |
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5MG | ¥405 | 有现货 |
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10MG | ¥648 | 有现货 |
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25MG | ¥1385 | 有现货 |
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50MG | ¥2373 | 有现货 |
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100MG | ¥4544 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称RS-127445
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
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产品描述RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5+/-0.1) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. RS-127445 potently antagonized 5-HT-evoked formation of inositol phosphates (pK(B) = 9.5+/-0.1) and 5-HT-evoked increases in intracellular calcium (pIC50 = 10.4+/-0.1). RS-127445 also blocked 5-HT-evoked contraction of rat isolated stomach fundus (pA2 = 9.5+/-1.1) and (+/-)alpha-methyl-5-HT-mediated relaxation of the rat jugular vein (pA2 = 9.9+/-0.3).
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同义词RS-127445; RS127445; MT-500
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通路Others
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靶点Other Targets
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受体5-HT2B; 5-HT2B
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number199864-87-4
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分子量281.33
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分子式C17H16FN3
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纯度98%
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溶解度——
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SMILESCC(C)C1=NC(N)=NC(=C1)C1=C2C=CC=CC2=C(F)C=C1
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化学全称2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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