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RMC-4550
CAS No. 2172651-73-7
RMC-4550 ( —— )
产品货号. M26806 CAS No. 2172651-73-7
RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥988 | 有现货 |
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| 10MG | ￥1604 | 有现货 |
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| 25MG | ￥3686 | 有现货 |
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| 50MG | ￥5443 | 有现货 |
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| 100MG | ￥7744 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称RMC-4550
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
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产品描述RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).(In Vitro):RMC-4550 stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide but lacks activity against the free catalytic domain of SHP2 .(In Vivo):RMC-4550 has moderate to high bioavailability and has a half-life amenable for once daily oral administration. In the EGFR-driven KYSE-520 human esophageal cancer xenograft model, RMC-4550 has a dose dependent efficacy consistent with target modulation, assessed by phospho-ERK inhibition in tumors. RMC-4550 is well tolerated at doses that achieved maximal and sustained efficacy in this model.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Phosphatase
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受体S. aureus
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研究领域——
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适应症——
化学信息
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CAS Number2172651-73-7
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分子量437.4
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分子式C21H26Cl2N4O2
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纯度>98% (HPLC)
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溶解度——
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SMILESC[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Jian-Ming, Shi-Chang, Sun, et al. Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antibiotic resistance of drug-resistant Staphylococcus aureus.[J]. International journal of antimicrobial agents, 2018.
产品手册
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