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RK-33

CAS No. 1070773-09-9

RK-33 ( RK-33 | RK 33 | RK33. )

产品货号. M17136 CAS No. 1070773-09-9

RK-33 是一流的 DDX3(一种 RNA 解旋酶)小分子抑制剂,可导致 G1 细胞周期停滞、诱导细胞凋亡并促进 DDX3 过表达细胞的放射增敏。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥527 有现货
5MG ¥956 有现货
10MG ¥1531 有现货
25MG ¥3208 有现货
50MG ¥4771 有现货
100MG ¥6796 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    RK-33
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    RK-33 是一流的 DDX3(一种 RNA 解旋酶)小分子抑制剂,可导致 G1 细胞周期停滞、诱导细胞凋亡并促进 DDX3 过表达细胞的放射增敏。
  • 产品描述
    RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
  • 体外实验
    RK-33 shows inhibition of many kinds of cancer cells with IC50 of 3-6 μM, while PC3 is much less sensitive to RK-33 (IC50 >12 μM). RK-33 treatment causes a significant accumulation in the G1 phase for DU145 and LNCaP, although treatment with RK-33 causes only a moderate accumulation of the G1 phase for 22Rv1, and the treated cells have significantly reduced G2 phase. RK-33 treatment also causes 12 moderate G1 accumulation in 22Rv1. RK-33-loaded NPs demonstrate cytotoxicity to MCF-7 cells in a dose-dependent manner, while equivalent doses of empty NPs have no killing effect. The IC50 value of 5% RK-33 loaded NPs is 49 μg/mL, and the IC50 value of 10% RK-33 loaded NPs is 25 μg/mL.
  • 体内实验
    There is more cell death (pyknotic or condensed nuclei) admixed with fibrin and interstitial edema in the tumors from mice from the combination RK-33 and radiation group compared to the control or single treatment groups. The treatment combination of RK-33 and radiation has an advantage in reducing tumor proliferation. In the mice treated with RK-33-PLGA, RK-33 can be detected in the plasma (34 μg/mL) and liver (28 μg/g), but not lungs.
  • 同义词
    RK-33 | RK 33 | RK33.
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    DDX3
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1070773-09-9
  • 分子量
    428.44
  • 分子式
    C23H20N6O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 50 mg/mL (116.70 mM)
  • SMILES
    COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
  • 化学全称
    3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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