RK-33
CAS No. 1070773-09-9
RK-33 ( RK-33 | RK 33 | RK33. )
产品货号. M17136 CAS No. 1070773-09-9
RK-33 是一流的 DDX3(一种 RNA 解旋酶)小分子抑制剂,可导致 G1 细胞周期停滞、诱导细胞凋亡并促进 DDX3 过表达细胞的放射增敏。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥527 | 有现货 |
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5MG | ¥956 | 有现货 |
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10MG | ¥1531 | 有现货 |
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25MG | ¥3208 | 有现货 |
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50MG | ¥4771 | 有现货 |
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100MG | ¥6796 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称RK-33
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述RK-33 是一流的 DDX3(一种 RNA 解旋酶)小分子抑制剂,可导致 G1 细胞周期停滞、诱导细胞凋亡并促进 DDX3 过表达细胞的放射增敏。
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产品描述RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
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体外实验RK-33 shows inhibition of many kinds of cancer cells with IC50 of 3-6 μM, while PC3 is much less sensitive to RK-33 (IC50 >12 μM). RK-33 treatment causes a significant accumulation in the G1 phase for DU145 and LNCaP, although treatment with RK-33 causes only a moderate accumulation of the G1 phase for 22Rv1, and the treated cells have significantly reduced G2 phase. RK-33 treatment also causes 12 moderate G1 accumulation in 22Rv1. RK-33-loaded NPs demonstrate cytotoxicity to MCF-7 cells in a dose-dependent manner, while equivalent doses of empty NPs have no killing effect. The IC50 value of 5% RK-33 loaded NPs is 49 μg/mL, and the IC50 value of 10% RK-33 loaded NPs is 25 μg/mL.
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体内实验There is more cell death (pyknotic or condensed nuclei) admixed with fibrin and interstitial edema in the tumors from mice from the combination RK-33 and radiation group compared to the control or single treatment groups. The treatment combination of RK-33 and radiation has an advantage in reducing tumor proliferation. In the mice treated with RK-33-PLGA, RK-33 can be detected in the plasma (34 μg/mL) and liver (28 μg/g), but not lungs.
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同义词RK-33 | RK 33 | RK33.
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通路Others
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靶点Other Targets
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受体DDX3
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研究领域Cancer
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适应症——
化学信息
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CAS Number1070773-09-9
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分子量428.44
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分子式C23H20N6O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (116.70 mM)
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SMILESCOC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
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化学全称3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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