RK-33 ( RK-33; RK 33; RK33. )

产品货号. M17136 CAS No. 1070773-09-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RK-33
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
产品描述

RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
同义词

RK-33; RK 33; RK33.
通路

Others
靶点

Other Targets
受体

DDX3
研究领域

Cancer
适应症

——

CAS Number

1070773-09-9
分子量

428.44
分子式

C23H20N6O3
纯度

98%
溶解度

——
SMILES

COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
化学全称

3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one

计算器

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