RK-24466

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RK-24466 是一种选择性且有效的 Lck 抑制剂，抑制 Lck (64-509) 和 LckCD 亚型，IC50 分别小于 1 和 2 nM。

RK-24466 is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.RK-24466, a lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, significantly inhibited both VSMC proliferation and migration. RK-24466 suppresses VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and extracellular signal regulated kinase (ERK) pathways, and it significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and cyclin D1 and, the phosphorylation of retinoblastoma protein (pRb). Additionally, RK-24466 suppressed the migration of VSMCs from endothelium-removed aortic rings, as well as neointima formation following rat carotid balloon injury. The present study identified RK-24466 as a potent VSMC proliferation and migration inhibitor and warrants further studies to elucidate its more detailed molecular mechanisms, such as its primary target, and to further validate its in vivo efficacy as a therapeutic agent for pathologic vascular conditions, such as restenosis and atherosclerosis.

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KIN 001-51

Tyrosine Kinase

Src

Lck

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213743-31-8

370.45

C23H22N4O

>98% (HPLC)

DMSO:40 mg/mL (107.97 mM; Need ultrasonic)

Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1

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(-20℃)

With Ice Pack

≥ 2 years