RIPK1-IN-7

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RIPK1-IN-7 是一种有效的选择性 RIPK1 抑制剂（Kd 为 4 nM，酶 IC50 为 11 nM），在实验性 B16 黑色素瘤肺转移模型中表现出优异的抗转移活性。

RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.(In Vitro):In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).

RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC50 of 2nM.RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively.

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Apoptosis

RIP kinase

Antifungal

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2300982-44-7

481.479

C25H22F3N5O2

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (129.81 mM)

CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12

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(-20℃)

With Ice Pack

≥ 2 years