RCM-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RCM-1 是 FOXM1 的抑制剂。 RCM-1 通过延长人类和小鼠癌细胞系的细胞周期和有丝分裂的持续时间来抑制细胞增殖。 RCM-1 在体外以剂量依赖性方式抑制癌细胞集落形成。 RCM-1在体外以剂量依赖性方式抑制癌细胞的迁移。

RCM-1 is an inhibitor of FOXM1. RCM-1 inhibits cellular proliferation via the increasing duration of cell cycle and mitosis in human and mouse cancer cell lines in vitro. RCM-1 inhibits colony formation of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the migration of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the initiation as well as the growth of cancer cell colonies in vitro. Treatment with RCM-1 increases the duration of mitosis and cell cycle in the cancer cell lines.RCM-1 decreases the B 16-FlO tumor growth as compared to the Vehicle -treated group. RCM-1 treatment decreases tumor cell proliferation and increased apoptosis in B16-FlO melanoma tumors. RCM-1 treatment reduces the growth of the human H2122 lung adenocarcinoma in mice. RCM-1 treatment reduces tumor cell proliferation and increases apoptosis in Rd76-9 rhabdomyosarcoma tumors. RCM-1 treatment decreases the growth of Rd76-9 rhabdomyosarcomas in mice. The RCM-1-treated Rd76-9 tumors display reduced FOXM1 staining and decreased expression of proliferation-specific markers Ki67 and PH3. Cleaved caspase staining is increased in the RCM-1 treated tumors, indicating an increase in apoptosis. RCM-1 treatment reduces the growth of B16-FlO melanoma tumors in mice.

RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1, a transcription factor critical for the differentiation of goblet cells from airway progenitor cells. In cultured airway epithelial cells, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3, which are key transcriptional regulators of goblet cell differentiation.

RCM-1 reduces airway resistance, increased lung compliance, and decreased proinflammatory cytokine production in mice exposed to the house dust mite and interleukin-13 (IL-13), which triggers goblet cell metaplasia. In mice, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3.

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Others

Other Targets

FOXM1

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339163-65-4

424.58

C20H12N2OS4

>98% (HPLC)

DMSO:16.67 mg/mL (39.26 mM; Need ultrasonic)

O=C(CSc1nc(cc(-c2cccs2)c1C#N)-c1cccs1)c1cccs1

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(-20℃)

With Ice Pack

≥ 2 years