Pterostilbene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

紫檀芪是一种天然酚类化合物，是白藜芦醇的二甲基化衍生物，对多种人类癌症类型具有有效的抗肿瘤活性。

Pterostilbene is a natural phenolic compound, dimethylated derivative of resveratrol that has potent antitumor activity against several human cancer types; induces strong and sustained activation of ERK1/2, with concomitant cyclin D1 suppression and p21 up-regulation, and inhibits the phosphorylation of AKT and mTOR in MDA-MB-468 cells; synergizes the antineoplastic effects of megestrol acetate in endometrial cancer; also targets MTA1/HDAC signaling with deacetylation of tumor suppressors p53 and PTEN in prostate cancer cells.(In Vitro):Pterostilbene (0, 5, 25, 50, 100, 200 and 400 μM) shows inhibitory activity against the growth of HeLa cells, with IC50s of 101.2 μM and 65.9 μM at 24 and 48 hrs, respectively. Ipterostilbene (0, 25, 100 and 200 μM) also induces the apoptosis HeLa cells.Pterostilbene (0.05, 0.1, 0.15 and 0.2 mM) has high anti-oxidant activity against DPPH, ABTS, hydroxyl, superoxide, hydrogen peroxide in a dose-dependent manner. Pterostilbene decreases lipid peroxides and hydroperoxides, reduces protein carbonyl groups and restores protein sulphydryl groups in response to damage by TBHP and As-Fe2+. Pterostilbene also inhibits single strand breaks in pBR322.(In Vivo):Pterostilbene (30?mg/kg daily, p.o. for 21 days) inhibits reactive oxygen species production in the animal model of inflammation.

Pterostilbene (0, 5, 25, 50, 100, 200 and 400 μM) shows inhibitory activity against the growth of HeLa cells, with IC50s of 101.2 μM and 65.9 μM at 24 and 48 hrs, respectively. Ipterostilbene (0, 25, 100 and 200 μM) also induces the apoptosis HeLa cells.?Pterostilbene (0.05, 0.1, 0.15 and 0.2 mM) has high anti-oxidant activity against DPPH, ABTS, hydroxyl, superoxide, hydrogen peroxide in a dose-dependent manner. Pterostilbene decreases lipid peroxides and hydroperoxides, reduces protein carbonyl groups and restores protein sulphydryl groups in response to damage by TBHP and As-Fe2+. Pterostilbene also inhibits single strand breaks in pBR322.

Pterostilbene (30mg/kg daily, p.o. for 21 days) inhibits reactive oxygen species production in the animal model of inflammation.

3',5'-Dimethoxy-4-Stilbenol | trans-3,5-Dimethoxy-4'-Hydroxystilbene

Natural Products

Phenols

Autophagy

Other Indications

——

537-42-8

256.301

C16H16O3

>98% (HPLC)

DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )

OC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1

4-Stilbenol, 3',5'-dimethoxy-, (E)- (8CI)

(-20℃)

With Ice Pack

≥ 2 years