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Psoralidin

CAS No. 18642-23-4

Psoralidin ( Psoralidin )

产品货号. M18153 CAS No. 18642-23-4

Psoralidin 抑制 Akt 磷酸化和磷脂酰肌醇 3-激酶激活和转录。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥462 有现货
10MG ¥786 有现货
25MG ¥1426 有现货
50MG ¥2122 有现货
100MG ¥3151 有现货
500MG ¥7152 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Psoralidin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Psoralidin 抑制 Akt 磷酸化和磷脂酰肌醇 3-激酶激活和转录。
  • 产品描述
    Psoralidin is a metabolic product from the seed of psoraleacorylifolia, possessing anti-inflammatory and immunomodulatory effects. Psoralidin inhibits lipopolysaccharide induced bone resorption by suppressing the inflammatory cytokines: TNF-α and IL-6 expression, as well as the ratio of RNAKL : OPG.
  • 体外实验
    Cell Viability Assay Cell Line:ALDH- cells, ALDH+ cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A) Concentration:10, 15, 50, and 25 μM Incubation Time:24?hours Result:IC50s of 18 to 21?μM for ALDH- cells, ALDH+ cells, commercial BCSCs. Apoptosis Analysis Cell Line:ALDH- cells, ALDH+ cells, and commercial BCSCs Concentration:20?and 30 μM Incubation Time:24?hours Result:No significant induction of apoptosis was observed for any of the three cell types following treatment at 20?μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30?μMin ALDH- cells, ALDH+ cells, and commercial BCSCs, respectively.
  • 体内实验
    Animal Model:BALB/c mice Dosage:5 mg/kg Administration:Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy).Result:Anti-inflammatory effect in IR-irradiated mice.
  • 同义词
    Psoralidin
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Akt| Phosphatidylinositol 3-kinase
  • 研究领域
    Others-Field
  • 适应症
    ——

化学信息

  • CAS Number
    18642-23-4
  • 分子量
    336.34
  • 分子式
    C20H16O5
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 50 mg/mL (148.66 mM)
  • SMILES
    CC(=CCc1c(cc2c(c1)c1c(c3c(o1)cc(cc3)O)c(=O)o2)O)C
  • 化学全称
    3,9-Dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Sun H, et al. J Pharm Sci. 2015 Jul;104(7):2369-77.
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