Prunin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Prunin 具有抗糖尿病和抗菌特性，可抑制蛋白酪氨酸磷酸酶 1B (PTP1B) 并刺激胰岛素抵抗 HepG2 细胞的葡萄糖摄取；它还可以刺激铜绿假单胞菌和不同芽孢杆菌的生长。

Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase.

Prunin exhibited dose-dependent inhibitory activity against ONOO--mediated tyrosine nitration and stimulated glucose uptake by decreasing PTP1B expression level in insulin-resistant HepG2 cells. Prunin shows significant inhibitory activity against α-glucosidase, with an IC50 of 317 ± 2.12 μM.

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Naringenin 7-0-glucoside

Microbiology/Virology

Antifection

Anti-infection|Phosphatase

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529-55-5

434.4

C21H22O10

>98% (HPLC)

DMSO:10 mM

O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13

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(-20℃)

With Ice Pack

≥ 2 years