Primin ( —— )

产品货号. M29217 CAS No. 15121-94-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Primin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimycobacterial, and strong antineoplastic actions.
产品描述

Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimycobacterial, and strong antineoplastic actions.(In Vitro):Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 = 0.144 μM) and Leishmania donovani (IC50 = 0.711 μM), and revealed low cytotoxicity (IC50 = 15.4 μM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum.(In Vivo):When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20 mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30 mg/kg, injected i.p.) in mice infected with L. donovani.
同义词

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通路

Microbiology/Virology
靶点

Antifection
受体

Anti-infection
研究领域

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适应症

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计算器

产品手册

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