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Pivagabine
CAS No. 69542-93-4
Pivagabine ( CXB-722 )
产品货号. M26382 CAS No. 69542-93-4
Pivagabine 是疏水性 4-氨基丁酸的衍生物，具有神经调节活性。匹伐加滨可穿透大鼠的血脑屏障。 Pivagabine 拮抗足部电击对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥381 | 有现货 |
|
| 5MG | ￥616 | 有现货 |
|
| 10MG | ￥1037 | 有现货 |
|
| 25MG | ￥2130 | 有现货 |
|
| 50MG | ￥3135 | 有现货 |
|
| 100MG | ￥4666 | 有现货 |
|
| 500MG | ￥9882 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Pivagabine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pivagabine 是疏水性 4-氨基丁酸的衍生物，具有神经调节活性。匹伐加滨可穿透大鼠的血脑屏障。 Pivagabine 拮抗足部电击对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
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产品描述Pivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.(In Vivo):Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.
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体外实验——
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体内实验Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions. Animal Model:Adult male Sprague-Dawley CD rats (200-250 g)Dosage:200 mg/kg Administration:i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result:Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex.
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同义词CXB-722
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通路Others
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靶点Other Targets
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受体Glutamate receptor
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研究领域——
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适应症——
化学信息
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CAS Number69542-93-4
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分子量187.239
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分子式C9H17NO3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (267.04 mM)
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SMILESCC(C)(C)C(=O)NCCCC(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Andersson M, et, al. Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia. Phytochemistry. 1995 Mar;38(4):835-6.
产品手册
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