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Pivagabine

CAS No. 69542-93-4

Pivagabine ( CXB-722 )

产品货号. M26382 CAS No. 69542-93-4

Pivagabine 是疏水性 4-氨基丁酸的衍生物,具有神经调节活性。匹伐加滨可穿透大鼠的血脑屏障。 Pivagabine 拮抗足部电击对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥381 有现货
5MG ¥616 有现货
10MG ¥1037 有现货
25MG ¥2130 有现货
50MG ¥3135 有现货
100MG ¥4666 有现货
500MG ¥9882 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Pivagabine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Pivagabine 是疏水性 4-氨基丁酸的衍生物,具有神经调节活性。匹伐加滨可穿透大鼠的血脑屏障。 Pivagabine 拮抗足部电击对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
  • 产品描述
    Pivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.(In Vivo):Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.
  • 体外实验
    ——
  • 体内实验
    Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions. Animal Model:Adult male Sprague-Dawley CD rats (200-250 g)Dosage:200 mg/kg Administration:i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result:Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex.
  • 同义词
    CXB-722
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Glutamate receptor
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    69542-93-4
  • 分子量
    187.239
  • 分子式
    C9H17NO3
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 50 mg/mL (267.04 mM)
  • SMILES
    CC(C)(C)C(=O)NCCCC(O)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Andersson M, et, al. Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia. Phytochemistry. 1995 Mar;38(4):835-6.
产品手册
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