Pivagabine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pivagabine 是疏水性 4-氨基丁酸的衍生物，具有神经调节活性。匹伐加滨可穿透大鼠的血脑屏障。 Pivagabine 拮抗足部电击对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。

Pivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.(In Vivo):Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.

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Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions. Animal Model:Adult male Sprague-Dawley CD rats (200-250 g)Dosage:200 mg/kg Administration:i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result:Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex.

CXB-722

Others

Other Targets

Glutamate receptor

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69542-93-4

187.239

C9H17NO3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (267.04 mM)

CC(C)(C)C(=O)NCCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years