
Pivagabine
CAS No. 69542-93-4
Pivagabine ( CXB-722 )
产品货号. M26382 CAS No. 69542-93-4
Pivagabine 是疏水性 4-氨基丁酸的衍生物,具有神经调节活性。匹伐加滨可穿透大鼠的血脑屏障。 Pivagabine 拮抗足部电击对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥381 | 有现货 |
![]() ![]() |
5MG | ¥616 | 有现货 |
![]() ![]() |
10MG | ¥1037 | 有现货 |
![]() ![]() |
25MG | ¥2130 | 有现货 |
![]() ![]() |
50MG | ¥3135 | 有现货 |
![]() ![]() |
100MG | ¥4666 | 有现货 |
![]() ![]() |
500MG | ¥9882 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Pivagabine
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Pivagabine 是疏水性 4-氨基丁酸的衍生物,具有神经调节活性。匹伐加滨可穿透大鼠的血脑屏障。 Pivagabine 拮抗足部电击对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
-
产品描述Pivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.(In Vivo):Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.
-
体外实验——
-
体内实验Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions. Animal Model:Adult male Sprague-Dawley CD rats (200-250 g)Dosage:200 mg/kg Administration:i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result:Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex.
-
同义词CXB-722
-
通路Others
-
靶点Other Targets
-
受体Glutamate receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number69542-93-4
-
分子量187.239
-
分子式C9H17NO3
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 50 mg/mL (267.04 mM)
-
SMILESCC(C)(C)C(=O)NCCCC(O)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Andersson M, et, al. Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia. Phytochemistry. 1995 Mar;38(4):835-6.
产品手册




关联产品
-
Oseltamivir Impurity...
3-Des(1-乙基丙氧基)-3-(1-甲基丙氧基)奥司他韦 (Oseltamivir EP Impurity F) 是抗病毒化合物奥司他韦的杂质。
-
Cepazine
Cefuroxime Axetil 是头孢菌素头孢呋辛的前体和一种广谱抗生素,可抑制几种革兰氏阳性和革兰氏阴性生物,包括那些最常与各种常见社区获得性感染相关的生物。
-
Rhodamine 123
Rhodamine 123 是一种荧光染料(λex=503 nm,λem=527 nm)。 R123 荧光强度在浓度为 50 μM 时出现峰值,并在较高浓度时由于自猝灭而降低至零。