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Pirtobrutinib
CAS No. 2101700-15-4
Pirtobrutinib ( LOXO-305 )
产品货号. M28068 CAS No. 2101700-15-4
Pirtobrutinib (LOXO-305) 是一种高度选择性、非共价的下一代 BTK 抑制剂，可抑制多种 BTK C481 替代突变。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥583 | 有现货 |
|
| 10MG | ￥1037 | 有现货 |
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| 25MG | ￥2406 | 有现货 |
|
| 50MG | ￥3702 | 有现货 |
|
| 100MG | ￥5443 | 有现货 |
|
| 500MG | ￥11583 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Pirtobrutinib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pirtobrutinib (LOXO-305) 是一种高度选择性、非共价的下一代 BTK 抑制剂，可抑制多种 BTK C481 替代突变。
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产品描述Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM.(In Vitro):Pirtobrutinib potently inhibits both wild-type BTK and BTK C481S-mediated kinase activity with nanomolar potency. Pirtobrutinib inhibits WT BTK (Y223) autophosphorylation with an IC50 of 3.68 nM. Pirtobrutinib inhibits BTK C481S Y223, C481T Y223, and C481R Y223 autophosphorylation with IC50s of 8.45, 7.23, and 11.73 nM, respectively.
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体外实验——
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体内实验——
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同义词LOXO-305
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通路Tyrosine Kinase
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靶点BTK
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受体8-oxoguanine DNA glycosylase 1 (OGG1)
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研究领域——
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适应症——
化学信息
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CAS Number2101700-15-4
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分子量479.43
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分子式C22H21F4N5O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (104.29 mM)
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SMILESN/A
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Baptiste BA, et al. Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention. Free Radic Biol Med. 2018 Aug 20;124:149-162.
