Pinosylvin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pinosylvin 通过 AMPK 激活诱导自噬。松西林可能充当促血管生成因子。

Pinosylvin induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.

Pinosylvin (0-100 μM; 24 hours) is cytotoxic to THP‐1 and U937 cells, exhibits an IC50 value of 20-30 μM in leukemia cells, the maximal cytotoxic effect occurred at 100 μM following incubation for 24?hr.Pinosylvin (0-100 μM; 24 hours) enhances the number of annexin V+?and PI+?cells in the U937 population at 50 μM, increasesannexin V+?and PI+ cells in the THP‐1 population at 100 μM.Pinosylvin (0-100 μM; 24 hours) promotesautophagy in leukemia cells by enhancing the level ofLC3‐II and p62/SQSTM1 degradation in leukemia cells. Cell Viability Assay Cell Line:Leukemia cells Concentration:0 μM; 0.1 μM; 1 μM; 10 μM; 50 μM; 100 μM Incubation Time:24 hours Result:Was cytotoxic to leukemia cells at high concentrations. Apoptosis Analysis Cell Line:U937 and THP‐1 cells Concentration:0 μM; 0.1 μM; 1 μM; 10 μM; 50 μM; 100 μM Incubation Time:24 hours Result:Induced apoptosis?cell number in U937 and THP‐1 cells.Western Blot Analysis Cell Line:U937 and THP‐1 cells Concentration:0 μM; 0.1 μM; 1 μM; 10 μM; 50 μM; 100 μM Incubation Time:24 hours Result:Induced autophagy in leukemia cells.?

Pinosylvin (intravenous injection; 10 mg/kg) yields the plasma AUC, urine t , CL and Vd values of 5.23 ± 1.20 mgh mL-1, 13.13 ± 2.05 h, 1.84 ± 0.44 Lh-1kg-1 and 2.29 Lkg-1, respectively in male Sprague-Dawley rats, in a PK study.

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Others

Other Targets

Others

Other Indications

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22139-77-1

212.248

C14H12O2

>98% (HPLC)

Soluble in DMSO

C1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)O)O

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(-20℃)

With Ice Pack

≥ 2 years