Picrocrocin

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Picrocrocin，一种在 Cochliobolus sativus 花中发现的类胡萝卜素。

Picrocrocin, an apocarotenoid found in the flowers of Cochliobolus sativus. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells.

Picrocrocin exerted growth inhibitory effects on the SK-MEL-2 melanoma cells. The IC50 of picrocrocin against the SK-MEL-2 cells was 20 μM at 24-h incubation. The antiproliferative activity of picrocrocin was due to apoptosis and cell cycle arrest. In addition, picrocrocin enhanced the ROS levels and decreased the MMP levels of SK-MEL-2 cells. Finally, picrocrocin inhibited the JAK/STAT5 signalling pathway in the SK-MEL-2 melanoma cells.

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Others

Other Targets

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138-55-6

330.37

C??H??O?

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (302.69 mM)

OC[C@H]([C@@H](O)[C@H](O)[C@H]1O)O[C@@]1([H])O[C@H]2CC(C)(C(C=O)=C(C)C2)C

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(-20℃)

With Ice Pack

≥ 2 years