Phellamurin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

苯酚素以剂量依赖性方式抑制肠道P-糖蛋白，苯酚素与环孢素存在严重的相互作用，为保证环孢素的疗效，建议避免苯酚或黄柏与环孢素合用。

Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.(In Vitro):Administration of 0-10?μg/mL Phellamurin for 48 hours in U2OS and Saos-2?cells leads to a repression of cell viability dose-dependently, promotes the apoptosis of U2OS and Saos-2?cells concentration-dependently, and declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2?cells.(In Vivo):Intraperitoneal injection of 50?mg/kg/day Phellamurin daily for 21 days in female BALB/c nude mice represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice.

Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment leads to a repression of cell viability in U2OS and Saos-2?cells in a dose-dependent manner.Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment concentration-dependently promots the apoptosis of U2OS and Saos-2?cells.Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2?cells. Cell Viability Assay Cell Line:U2OS and Saos-2?cells Concentration:0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10?μg/mL Incubation Time:48 hours Result:Suppressed the viability of U2OS and Saos-2?cells in a concentration-dependent manner.Apoptosis Analysis Cell Line:U2OS and Saos-2?cells Concentration:0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10?μg/mL Incubation Time:48 hours Result:Induced apoptosis of U2OS and Saos-2?cells in a concentration-dependent manner.Western Blot Analysis Cell Line:U2OS and Saos-2?cells Concentration:0 μg/mL and 10?μg/mL Incubation Time:48 hours Result:Repressed the PI3K/AKT/mTOR pathway in U2OS and Saos-2?cells.

Phellamurin (50?mg/kg/day; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice. Animal Model:Athymic female BALB/c nude mice (6 weeks old ) injected with U2OS cells Dosage:50?mg/kg/day Administration:Intraperitoneal injection; daily; for 21 days Result:Repressed osteosarcoma tumor growth in vivo.

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Membrane Transporter/Ion Channel

P-glycoprotein

P-gp

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52589-11-4

518.51

C26H30O11

>98% (HPLC)

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CC(C)=CCc(c(O[C@@H]([C@H](C1=O)O)c(cc2)ccc2O)c1c(O)c1)c1O[C@@H]([C@@H]([C@H]1O)O)O[C@H](CO)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years