Pentoxifylline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pentoxifylline (BL-191) 是一种血液流变学改善剂。Pentoxifylline 是一种具有口服活性的，非选择性的磷酸二酯酶 (PDE) 抑制剂，具有免疫调节、抗炎、血液流变学改善、抗纤溶和抗增殖作用。Pentoxifylline 可用于研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。

A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production. (In Vitro):Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.Pentoxifylline results in high LC3-II/LC3-ratio.(In Vivo):Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment.

Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells. Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.Pentoxifylline results in high LC3-II/LC3-ratio. Cell Proliferation Assay Cell Line:MDA-MB-231 cells Concentration:0.1 mM, 1 mM, 5 mM , 10 mM, 50 mM Incubation Time:24 hours, 48 hoursResult:Inhibited cell proliferation in a dose-dependent manner.Apoptosis Analysis Cell Line:MDA-MB-231 cells Concentration:0.5 mM Incubation Time:12 hours, 24 hours, 36 hours Result:Induced apoptosis.Cell Autophagy AssayCell Line:MDA-MB-231 cellsConcentration:0.5 mM Incubation Time:24 hours, 48 hours Result:Induced approximately 20-28% of cell autophagy.Cell Cycle Analysis Cell Line:MDA-MB-231 cells Concentration:0.5 mM Incubation Time:24 hours, 48 hours Result:Induced G0/G1 phase arrest.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:0.5 mM Incubation Time:24 hours, 48 hours Result:Induced high LC3-II/LC3-ratio.

Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment. Animal Model:Adult male Wistar rats 12-13-weeks-old (250-300 g)Dosage:200 mg/kg Administration:Intraperitoneal injection, at 1hr before and 3 hr after ischemia Result:Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups.

NSC 637086 | Oxpentifylline

Apoptosis

Adenosine Receptor

A2| PDE

Cardiovascular Disease

——

6493-05-6

278.31

C13H18N4O3

>98% (HPLC)

soluble in Water

c12c(n(c(=O)n(c1=O)CCCCC(C)=O)C)ncn2C

1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion

(-20℃)

With Ice Pack

≥ 2 years