Pentagastrin ( Pentagastrin | NCGC00183362-01 | Pentagastrinum | Peptavlon )

产品货号. M18800 CAS No. 5534-95-2

五肽胃泌素是一种合成多肽，胃肠外给药时具有类似胃泌素的作用，可引起唾液蛋白的分泌和合成。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥381	有现货
10MG	￥535	有现货
25MG	￥1102	有现货
50MG	￥1823	有现货
100MG	￥2908	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Pentagastrin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

五肽胃泌素是一种合成多肽，胃肠外给药时具有类似胃泌素的作用，可引起唾液蛋白的分泌和合成。
产品描述

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test. Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system.(In Vitro):Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold.Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells.(In Vivo):Pentagastrin (ICI-50123) (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury.
体外实验

Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold.Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells.
体内实验

Pentagastrin (ICI-50123) (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury. Animal Model:Male Sprague-Dawley rats (approximately 200 g) Dosage:80 μg/kg/h Administration:Intravenous injection Result:Protected rat gastric mucosa from acidified aspirin injury. Induced a hyperaemic response to luminal acid challenge, increased mucus gel thickness, and elevated pHi during acid challenge.
同义词

Pentagastrin | NCGC00183362-01 | Pentagastrinum | Peptavlon
通路

Others
靶点

Other Targets
受体

Others
研究领域

Cancer
适应症

——

化学信息

CAS Number

5534-95-2
分子量

767.89
分子式

C37H49N7O9S
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 34 mg/mL; 44.28 mM
SMILES

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
化学全称

(3S)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid