Peldesine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Peldesine is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase.

Peldesine is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection.(In Vitro):The IC50s are 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell purine nucleoside phosphorylase, respectively. In Jurkat cells, Peldesine (BCX 34; 0-50 μM; 72 hours) inhibits the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine.(In Vivo):Peldesine is orally active in elevating plasma inosine in rats (2-fold at 30 mg/kg), in suppressing ex vivo RBC PNP activity in rats (98% at 3 h. 100 mg/kg), and in suppressing ex vivo skin PNP in mice (39% at 3 h, 100 mg/kg). Oral bioavailability of Peldesine in rats is 76%.

BCX 34

Others

Other Targets

GSTP1; Gutathione S-transferase

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133432-71-0

241.3

C12H11N5O

>98% (HPLC)

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Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1

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(-20℃)

With Ice Pack

≥ 2 years