Pefloxacin ( Pefloxacin | 1584RB | 1589 RB | EU 5306 EU-5306 | Pefloxacinium )

产品货号. M15706 CAS No. 70458-92-3

Pefloxacin 是一种抗菌剂，通过抑制 DNA 旋转酶（拓扑异构体）来防止细菌 DNA 复制。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Pefloxacin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Pefloxacin 是一种抗菌剂，通过抑制 DNA 旋转酶（拓扑异构体）来防止细菌 DNA 复制。
产品描述

Pefloxacin is a an antibacterial agent and prevents bacterial Dna replication by inhibiting Dna gyrase (topoisomerse) Target: Dna gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections. Pefloxacin is commonly referred to as afluoroquinolone (or quinolone) drug and is a member of the fluoroquinolone class of antibacterials. It is an analog of norfloxacin. It is a synthetic fluoroquinolone, belonging to the 3rd generation of quinolones. Pefloxacin is extensively prescribed in France. Pefloxacin has not been approved for use in the United States. The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes Dna gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial Dna. Dna gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result Dna replication and transcription is inhibited.
体外实验

——
体内实验

——
同义词

Pefloxacin | 1584RB | 1589 RB | EU 5306 EU-5306 | Pefloxacinium
通路

GPCR/G Protein
靶点

Antibacterial
受体

——
研究领域

Infection
适应症

——

化学信息

CAS Number

70458-92-3
分子量

333.36
分子式

C17H20FN3O3
纯度

>98% (HPLC)
溶解度

N/A
SMILES

O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCN(C)CC3)=C2)C1=O)O
化学全称

3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Drlica K, et al. Dna gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. 2. Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus Dna polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册