
Panaxadiol
CAS No. 19666-76-3
Panaxadiol ( 20(R)-Panaxadiol )
产品货号. M18191 CAS No. 19666-76-3
Panaxadiol (20(R)-Panaxadiol) 是一种具有口服活性的 HIF-1α/STAT3 抑制剂。Panaxadiol 可以抑制 HIF-1α 和 STAT3,然后导致 programmed cell death-ligand 1 (PD-L1) 表达的下调。Panaxadiol 具有抗癌、保护心脏、抗心律失常和抗氧化的活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
50MG | ¥405 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Panaxadiol
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Panaxadiol (20(R)-Panaxadiol) 是一种具有口服活性的 HIF-1α/STAT3 抑制剂。Panaxadiol 可以抑制 HIF-1α 和 STAT3,然后导致 programmed cell death-ligand 1 (PD-L1) 表达的下调。Panaxadiol 具有抗癌、保护心脏、抗心律失常和抗氧化的活性。
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产品描述Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
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体外实验Panaxadiol (1-10 μM, 12 h) inhibits PD-L1 expression in human colon cancer cells.Panaxadiol (1-10 μM, 12 h) inhibits the expression of PD-L1 by suppressing HIF-1α and STAT3 in HCT116 cells. Western Blot AnalysisCell Line:HCT116, SW620 and HT-29 colon cancer cells Concentration:1, 3, and 10 μM Incubation Time:12 hours Result:Decreased the expression of PD-L1 protein and mRNA in a dose-dependent manner.Western Blot Analysis Cell Line:HCT116 cells Concentration:1, 3, and 10 μM Incubation Time:12 hours Result:Inhibited hypoxia-induced nuclear accumulation of HIF-1α in a dose-dependent manner.Inhibited STAT3 phosphorylation at Tyr705 in a dose-dependent manner under both normoxic and hypoxic conditions.
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体内实验Panaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model. Animal Model:BALB/c athymic nude mice injected with HCT116 cells Dosage:10 or 30 mg/kg Administration:Oral gavage; 10 or 30 mg/kg; once every 3 days; 30 days Result:Inhibited the protein levels of HIF-1α, p-STAT-3 (Tyr705), PD-L1 and VEGF in tumour tissues in a dose-dependent manner.
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同义词20(R)-Panaxadiol
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通路Others
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靶点Other Targets
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受体Others
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研究领域Cancer
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适应症——
化学信息
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CAS Number19666-76-3
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分子量460.73
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分子式C30H52O3
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纯度>98% (HPLC)
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溶解度Ethanol : 20 mg/mL 43.41 mM;
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SMILESO[C@H]1[C@H]2[C@]([C@]3([C@@H]([C@@]4([C@@H](CC3)C([C@@H](O)CC4)(C)C)C)C1)C)(CC[C@@H]2[C@@]1(OC(CCC1)(C)C)C)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lin X, et al. Exp Hematol. 2015 May;43(5):364-73.
产品手册




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