PU23

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PU 23 是多重耐药蛋白 4 (MRP4) 的抑制剂。

PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).(In Vitro):6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. The combination of PU23 and 6-MP inhibits HEK293 and HEK293/MRP4 cells with IC50s of 1.84 and 6.06 μM, respectively.Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 h also significantly increases the amount of 6-MP in cells .

6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. The combination of PU 23 (Cpd23) and 6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 1.84 and 6.06 μM, respectively.Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 h also significantly increases the amount of 6-MP in cells.

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Endocrinology/Hormones

MRP

MRP

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817635-93-1

425.52

C21H19N3O3S2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (293.76 mM)

O=C(NC(=S)NC1=CC=C(C=C1)S(=O)(=O)NCC1=CC=CC=C1)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years