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PTP1B-IN-9
CAS No. 145888-79-5
PTP1B-IN-9 ( —— )
产品货号. M22017 CAS No. 145888-79-5
PTP1B-IN-9 是一种泛素蛋白酶体系统 (UPS) 应激源，具有抗癌活性。 PTP1B-IN-9 以剂量依赖性方式降低指数生长的 HeLa 宫颈癌细胞的细胞活力，IC50 值为 2 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥616 | 有现货 |
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| 50MG | ￥1677 | 有现货 |
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| 100MG | ￥2770 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PTP1B-IN-9
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PTP1B-IN-9 是一种泛素蛋白酶体系统 (UPS) 应激源，具有抗癌活性。 PTP1B-IN-9 以剂量依赖性方式降低指数生长的 HeLa 宫颈癌细胞的细胞活力，IC50 值为 2 μM。
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产品描述PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM.
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体外实验RAMB4 (0-30 μM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively.RAMB4 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM. Cell Viability Assay Cell Line:Keratinocytes, SiHa, CaSki and ME180 cells Concentration:5, 10, 15, 20, 25, 30 μM Incubation Time:48 hours Result:Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.
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体内实验——
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同义词——
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通路Proteasome/Ubiquitin
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靶点Proteasome
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受体Proteasome
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研究领域——
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适应症——
化学信息
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CAS Number145888-79-5
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分子量413.1
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分子式C19H13Cl4NO?
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 5 mg/mL (12.10 mM)
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SMILESClC1=CC=C(\\C=C2/CNC\\C(=C/C3=CC(Cl)=C(Cl)C=C3)C2=O)C=C1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Anchoori RK, et al. Stressing?the?ubiquitin-proteasome?system?without?20S?proteolytic?inhibition?selectively?kills?cervical?cancer?cells.PLoS One.?2011;6(8):e23888.
