021-51111890
购物车（0）
sales@molnova.cn
PMX53
CAS No. 219639-75-5
PMX53 ( PMX 53 | Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg )
产品货号. M13502 CAS No. 219639-75-5
PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) 是一种有效的 C5a 受体 (CD88) 拮抗剂，IC50 为 20 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥5581 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称PMX53
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) 是一种有效的 C5a 受体 (CD88) 拮抗剂，IC50 为 20 nM。
-
产品描述PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM, also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells; PMX-53 (10 nM) inhibited C5a-induced Ca(2+) mobilization in HMC-1 cells, but at higher concentrations (>30 nM) it caused degranulation in LAD2 mast cells, CD34(+) cell-derived mast cells, and RBL-2H3 cells stably expressing MrgX2; inhibits zymosan-, carrageenan-, LPS- and antigen-induced hypernociception in rats.
-
体外实验——
-
体内实验Animal Model:Adult male Wistar rats (weighing 180-200?g) injected with zymosan Dosage:0.3 mg/kg, 1 mg/kg or 3?mg/kg Administration:Subcutaneous injection; once Result:Inhibited the hypernociception induced by zymosan-activated serum and C5a.
-
同义词PMX 53 | Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg
-
通路Immunology/Inflammation
-
靶点Complement System
-
受体Complement System
-
研究领域——
-
适应症——
化学信息
-
CAS Number219639-75-5
-
分子量896.1
-
分子式C47H65N11O7
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 200 mg/mL (223.19 mM)
-
SMILESN=C(NCCC[C@H](NC([C@@H](NC([C@H](NC([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC(C)=O)CC2=CC=CC=C2)=O)CCCN3)=O)=O)CC4CCCCC4)=O)CC5=CNC6=C5C=CC=C6)=O)C3=O)N
-
化学全称Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Ting E, et al. Br J Pharmacol. 2008 Mar;153(5):1043-53.
2. Subramanian H, et al. Mol Pharmacol. 2011 Jun;79(6):1005-13.
3. Liu H, et al. Nat Struct Mol Biol. 2018 Jun;25(6):472-481.
4. Finch AM, et al. J Med Chem. 1999 Jun 3;42(11):1965-74.
产品手册
关联产品
-
PMX 53 acetate(21963...
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
-
BR103
BR103 是一种有效的、代谢稳定的、高选择性的补体 C3a 受体 (C3aR) 小分子激动剂，EC50 为 22 ± 8 nM。
-
Ravulizumab
Ravulizumab (ALXN1210) 是一种人源化单克隆抗体，它以高亲和力特异性结合人补体蛋白 C5。Ravulizumab 可用于阵发性睡眠性血红蛋白尿症、非典型溶血性尿毒症综合征和重症肌无力的研究。
