PI-828

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PI-828 是一种双重 PI3K 和 casein kinase 2 (CK2) 抑制剂，抑制 p110α，CK2 和 CK2α2，IC50 分别为 173 nM，149 nM 和 1127 nM。

PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells. PI-828 (0.78-3.12 μM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.Cell Viability Assay Cell Line:4T1 breast cancer cells and 4306 ovarian cancer cells Concentration:0.01, 0.1, 1, 10 and 100 μM Incubation Time:Result:Exhibited cytotoxic effect.Apoptosis Analysis Cell Line:Human embryonic carcinoma NCCIT cells Concentration: 0.78, 1.56, 3.12, 6.25, 12.5 μM Incubation Time:48 hours Result:Concentrations of ranging from 0.78 to 3.12 μM decreased caspase 3 activation; higher concentrations caused apoptosis.

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PI3K/Akt/mTOR signaling

PI3K

PI3K | Casein Kinase

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942289-87-4

322.36

C19H18N2O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 12.5 mg/mL (38.78 mM )

Nc1ccc(cc1)-c1cccc2c1oc(cc2=O)N1CCOCC1

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(-20℃)

With Ice Pack

≥ 2 years