
PH-002
CAS No. 1311174-68-1
PH-002 ( —— )
产品货号. M23470 CAS No. 1311174-68-1
PH-002 是神经元细胞中载脂蛋白 (apo) E4 分子内结构域相互作用的抑制剂。它还可以挽救线粒体运动和神经突生长的损伤。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥786 | 有现货 |
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10MG | ¥1442 | 有现货 |
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25MG | ¥3216 | 有现货 |
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50MG | ¥4771 | 有现货 |
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100MG | ¥6828 | 有现货 |
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200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称PH-002
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述PH-002 是神经元细胞中载脂蛋白 (apo) E4 分子内结构域相互作用的抑制剂。它还可以挽救线粒体运动和神经突生长的损伤。
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产品描述PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.
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体外实验PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an IC50 of 116 nM in FRET.
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体内实验PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons).
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同义词——
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通路Others
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靶点Other Targets
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受体Apo E4 in FRET
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研究领域——
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适应症——
化学信息
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CAS Number1311174-68-1
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分子量491.58
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分子式C27H33N5O4
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纯度>98% (HPLC)
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溶解度DMSO:75 mg/mL (152.57 mM)
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SMILESCC(C)(C)OC(N1CCN(Cc(cc2)ccc2NC(CC(c2c3cccc2)=NN(C)C3=O)=O)CC1)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Brodbeck J, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13;286(19):17217-26.
产品手册




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