PF-8380 ( PF8380; PF-8380; PF 8380 )

产品货号. M10512 CAS No. 1144035-53-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PF-8380
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Potent autotaxin inhibitor (IC50= 2.8 nM in isolated enzyme assay; 101 nM in human whole blood).
产品描述

Potent autotaxin inhibitor (IC50= 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levelsin vivoandin vitroby directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Orally available.
同义词

PF8380; PF-8380; PF 8380
通路

Angiogenesis
靶点

PDE
受体

Autotaxin
研究领域

Inflammation/Immunology
适应症

——

CAS Number

1144035-53-9
分子量

478.33
分子式

C22H21Cl2N3O5
纯度

>98%(HPLC)
溶解度

DMSO: 95 mg/mL (198.6 mM)
SMILES

O=C(N1CCN(CCC(C2=CC=C3NC(OC3=C2)=O)=O)CC1)OCC4=CC(Cl)=CC(Cl)=C4
化学全称

3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate

1. Gierse J, et al. J Pharmacol Exp Ther. 2010, 334(1):310-317.

计算器

产品手册

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