PF-543 ( Sphingosine Kinase 1 Inhibitor II )

产品货号. M18007 CAS No. 1415562-82-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PF-543
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PF-543 是一种新型鞘氨醇竞争性 SphK1 抑制剂，可抑制 SphK1，IC50 和 Ki 分别为 2.0 nM 和 3.6 nM。
产品描述

PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
体外实验

Western Blot Analysis Cell Line:Human pulmonary arterial smooth muscle (PASM) cells Concentration:10 nM, 100 nM, 1000 nM Incubation Time:24 ?hours Result:Abolished SK1 expression at nM concentrations.Apoptosis Analysis Cell Line:Human pulmonary arterial smooth muscle (PASM) cells Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:24 ?hours Result:Induced caspase-3/7 activity in cultured human pulmonary smooth muscle cells.
体内实验

Animal Model:Female C57BL/6 J mice (7-12 week-old) with hypoxic-induced pulmonary arterial hypertension Dosage:1 mg/kg Administration:Intraperitoneal injection; every second day; for 21 days Result:Reduced right ventricular hypertrophy. The protection involves a reduction in the expression of p53 (that promotes cardiomyocyte death) and an increase in the expression of anti-oxidant nuclear factor Nrf-2.
同义词

Sphingosine Kinase 1 Inhibitor II
通路

Others
靶点

Other Targets
受体

SphK1| SphK1
研究领域

Cancer
适应症

——

1. Schnute ME, et al. Biochem J, 2012, 444(1), 79-88.

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