
PF-543
CAS No. 1415562-82-1
PF-543 ( Sphingosine Kinase 1 Inhibitor II )
产品货号. M18007 CAS No. 1415562-82-1
PF-543 是一种新型鞘氨醇竞争性 SphK1 抑制剂,可抑制 SphK1,IC50 和 Ki 分别为 2.0 nM 和 3.6 nM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥405 | 有现货 |
![]() ![]() |
5MG | ¥632 | 有现货 |
![]() ![]() |
10MG | ¥940 | 有现货 |
![]() ![]() |
25MG | ¥1766 | 有现货 |
![]() ![]() |
100MG | 获取报价 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称PF-543
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述PF-543 是一种新型鞘氨醇竞争性 SphK1 抑制剂,可抑制 SphK1,IC50 和 Ki 分别为 2.0 nM 和 3.6 nM。
-
产品描述PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
-
体外实验Western Blot Analysis Cell Line:Human pulmonary arterial smooth muscle (PASM) cells Concentration:10 nM, 100 nM, 1000 nM Incubation Time:24 ?hours Result:Abolished SK1 expression at nM concentrations.Apoptosis Analysis Cell Line:Human pulmonary arterial smooth muscle (PASM) cells Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:24 ?hours Result:Induced caspase-3/7 activity in cultured human pulmonary smooth muscle cells.
-
体内实验Animal Model:Female C57BL/6 J mice (7-12 week-old) with hypoxic-induced pulmonary arterial hypertension Dosage:1 mg/kg Administration:Intraperitoneal injection; every second day; for 21 days Result:Reduced right ventricular hypertrophy. The protection involves a reduction in the expression of p53 (that promotes cardiomyocyte death) and an increase in the expression of anti-oxidant nuclear factor Nrf-2.
-
同义词Sphingosine Kinase 1 Inhibitor II
-
通路Others
-
靶点Other Targets
-
受体SphK1| SphK1
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1415562-82-1
-
分子量465.6
-
分子式C27H31NO4S
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 100 mg/mL (214.78 mM)
-
SMILESC(O)[C@@H]1N(CCC1)Cc1ccc(cc1)COc1cc(cc(c1)C)CS(=O)(=O)c1ccccc1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Schnute ME, et al. Biochem J, 2012, 444(1), 79-88.
产品手册




关联产品
-
Euquinine
Euquinine 是一种无味的盐,可作为奎宁的替代物。Euquinine 具有抗恶性疟原虫活性。Euquinine 可用于恶性疟原虫多重耐药及其生物利用度的研究。
-
ELA-21 (human)
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
-
Anemarsaponin E
从 Anemarrhena asphodeloides 中提取的皂苷,并具有抗炎活性。