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PF-1355

CAS No. 1435467-38-1

PF-1355 ( PF-06281355 | PF 06281355 | ZINC205721785 )

产品货号. M28021 CAS No. 1435467-38-1

PF-1355 是一种基于 2-硫氧嘧啶机制的选择性 MPO 抑制剂。 PF-1355用于治疗血管炎疾病。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥356 有现货
5MG ¥583 有现货
10MG ¥988 有现货
25MG ¥1604 有现货
50MG ¥3013 有现货
100MG ¥4350 有现货
200MG ¥6221 有现货
500MG ¥9315 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    PF-1355
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    PF-1355 是一种基于 2-硫氧嘧啶机制的选择性 MPO 抑制剂。 PF-1355用于治疗血管炎疾病。
  • 产品描述
    PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.(In Vitro):PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM) .(In Vivo):Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment .
  • 体外实验
    In a dose-responsive fashion, PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM).
  • 体内实验
    Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Good pasture disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment.
  • 同义词
    PF-06281355 | PF 06281355 | ZINC205721785
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Antifungal
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1435467-38-1
  • 分子量
    321.35
  • 分子式
    C14H15N3O4S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 50 mg/mL (155.59 mM)
  • SMILES
    O=C1C=C(C=2C=C(OC)C=CC2OC)N(C(=S)N1)CC(=O)N
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Prats E, et al. Antifungal activity of a new phenolic compound from capitulum of a head rot-resistant sunflower genotype. J Chem Ecol.?2007 Dec;33(12):2245-53. Epub 2007 Nov 22.
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