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PF-1355
CAS No. 1435467-38-1
PF-1355 ( PF-06281355; PF 06281355; ZINC205721785 )
产品货号. M28021 CAS No. 1435467-38-1
PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥356 | 有现货 |
|
| 5MG | ￥583 | 有现货 |
|
| 10MG | ￥988 | 有现货 |
|
| 25MG | ￥1604 | 有现货 |
|
| 50MG | ￥3013 | 有现货 |
|
| 100MG | ￥4350 | 有现货 |
|
| 200MG | ￥6221 | 有现货 |
|
| 500MG | ￥9315 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF-1355
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
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产品描述PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.(In Vitro):PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM) .(In Vivo):Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment .
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同义词PF-06281355; PF 06281355; ZINC205721785
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通路Others
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靶点Other Targets
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受体Antifungal
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研究领域——
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适应症——
化学信息
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CAS Number1435467-38-1
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分子量321.4
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分子式C14H15N3O4S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1C=C(C=2C=C(OC)C=CC2OC)N(C(=S)N1)CC(=O)N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Prats E, et al. Antifungal activity of a new phenolic compound from capitulum of a head rot-resistant sunflower genotype. J Chem Ecol.?2007 Dec;33(12):2245-53. Epub 2007 Nov 22.
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