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PF-06648671
CAS No. 1587727-31-8
PF-06648671 ( PF6648671 )
产品货号. M12266 CAS No. 1587727-31-8
PF-06648671 (PF6648671) 是一种新型口服γ-分泌酶调节剂，正在开发用于治疗阿尔茨海默病。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥8068 | 有现货 |
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| 50MG | ￥28998 | 有现货 |
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| 100MG | ￥39690 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF-06648671
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PF-06648671 (PF6648671) 是一种新型口服γ-分泌酶调节剂，正在开发用于治疗阿尔茨海默病。
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产品描述PF-06648671 (PF6648671) is a novel oral γ-secretase modulator being developed for the treatment of Alzheimer's disease.Alzheimer Disease Phase 1 Discontinued.
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体外实验In a cell-based assay, PF-06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates.
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体内实验PF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals.
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同义词PF6648671
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通路Wnt/Notch/Hedgehog
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靶点γ-secretase
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受体γ-secretase
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研究领域——
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适应症——
化学信息
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CAS Number1587727-31-8
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分子量538.928
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分子式C25H23ClF4N4O3
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1C(N2CCN1[C@H]([C@H]3O[C@@H](C4=CC(F)=C(Cl)C=C4C(F)(F)F)CC3)C)=CC=C(N5C=C(C)N=C5)C2=O
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化学全称2H-Pyrido[1,2-a]pyrazine-1,6-dione, 2-[(1S)-1-[(2S,5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]tetrahydro-2-furanyl]ethyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
