PF-03049423 ( PF 03049423 )

产品货号. M14380 CAS No. 402955-58-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PF-03049423
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.
产品描述

PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.Stroke Phase 2 Discontinued
同义词

PF 03049423
通路

Angiogenesis
靶点

PDE
受体

PDE
研究领域

Neurological Disease
适应症

Stroke

CAS Number

402955-58-2
分子量

468.55
分子式

C24H32N6O4
纯度

>98% (HPLC)
溶解度

——
SMILES

CCCOCCN1C2=CC(=NC=C2N=C(C1=O)N3CCN(CC3)CCO)C4=CN=C(C=C4)OC.Cl
化学全称

3-[4-(2-Hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)-pyrido[3,4-b]pyrazin-2(1H)-one

1. Hughes RO, et al. J Med Chem. 2010 Mar 25;53(6):2656-60.
2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9.

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