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PDK4-IN-1
CAS No. 2310262-10-1
PDK4-IN-1 ( —— )
产品货号. M21874 CAS No. 2310262-10-1
PDK4-IN-1 是一种蒽醌衍生物，是丙酮酸脱氢酶激酶 4 (PDK4) 的有效口服活性抑制剂（IC50 值为 84 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PDK4-IN-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PDK4-IN-1 是一种蒽醌衍生物，是丙酮酸脱氢酶激酶 4 (PDK4) 的有效口服活性抑制剂（IC50 值为 84 nM）。
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产品描述PDK4-IN-1 treatment significantly impedes the proliferation of human colon cancer cell lines, HCT116 and RKO. The colony formation efficiency in HCT116 and RKO cells Is significantly reduced after treatment of PDK4-IN-1. PDK4-IN-1 (Compound 8c; 10-50 μM; 24 hours; HCT116 and RKO cells) treatment dose-dependently increased apoptosis. PDK4-IN-1 (compound 8c)-induced phosphorylation of p53 on serine 15 is a dose-dependent response in both HCT116 and RKO cells. PDK4-IN-1 decreases the expression of BCL-xL and increases the expression of BAX. Cleavage of PARP1 and caspase 3 are increased by PDK4-IN-1.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Pyruvate dehydrogenase kinase 4 (PDK4),84 nM
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研究领域——
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适应症——
化学信息
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CAS Number2310262-10-1
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分子量357.41
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分子式C22H19N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lee D, et al. Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases. J Med Chem. 2019 Jan 24;62(2):575-588.
