PBT-1033

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PBT-1033(PBT-2) 是一种潜在的神经保护剂，用于治疗阿尔茨海默病和亨廷顿舞蹈病。

PBT-1033(PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.

PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5?μM.PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity.PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons.PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells.PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates. Western Blot Analysis Cell Line:SH-SY5Y cells Concentration:0-10 μM Incubation Time:1 h Result:Increased in cellular levels of GSK3α/β phosphorylated at the inhibitory serine 21/9 residue (ser21/9 on GSK3α/β).

PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease. Animal Model:Female Tg2576 miceDosage:30 mg/kg/d Administration:Oral administration, 11 days Result:Increased hippocampal apical spine density, basal spine density.

PB 1033 | PBT-2 | PBT1033 | PBT2 | PBT 1033 | PBT 2

Others

Other Targets

others

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747408-78-2

271.14

C12H12Cl2N2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (368.81 mM)

CN(C)Cc1ccc(c(Cl)cc(Cl)c2O)c2n1

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(-20℃)

With Ice Pack

≥ 2 years