PBIT
CAS No. 2514-30-9
PBIT ( —— )
产品货号. M22946 CAS No. 2514-30-9
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes . PBIT, which inhibits JARID1B with an IC50 of about 3 μm in vitro.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥389 | 有现货 |
|
5MG | ¥648 | 有现货 |
|
10MG | ¥1037 | 有现货 |
|
25MG | ¥2333 | 有现货 |
|
50MG | ¥3872 | 有现货 |
|
100MG | ¥5581 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称PBIT
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes . PBIT, which inhibits JARID1B with an IC50 of about 3 μm in vitro.
-
产品描述PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes . PBIT, which inhibits JARID1B with an IC50 of about 3 μm in vitro.?Consistent with this, PBIT treatment inhibited removal of H3K4me3 by JARID1B in cells.?Furthermore, this compound inhibited proliferation of cells expressing higher levels of JARID1B.?
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体JARID1B;JARID1A;JARID1C
-
研究领域——
-
适应症——
化学信息
-
CAS Number2514-30-9
-
分子量241.31
-
分子式C14H11NOS
-
纯度>98% (HPLC)
-
溶解度DMSO:100 mg/mL (414.40 mM; Need ultrasonic)
-
SMILESO=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.
产品手册
关联产品
-
Chrysin 6-C-glucosid...
Chrysin 6-C-glucoside is a natural product of Psidium, Myrtaceae. Chrysin 6-C-glucoside can be used as a reference standard.
-
Bonaid TM
(E)-[6]-Dehydroparadol shows growth inhibition and induction of apoptosis against human cancer cells(IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively).
-
GNF-5837
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).