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PBIT
CAS No. 2514-30-9
PBIT ( —— )
产品货号. M22946 CAS No. 2514-30-9
PBIT 抑制 JARID1B 组蛋白去甲基酶（IC50 约为 3 μM）。 PBIT 还抑制 JARID1A 和 JARID1C（IC50 分别为 6 μM 和 4.9 μM）。 PBIT 是富含 Jumonji AT 的交互域 1 (JARID1) 酶的特异性抑制剂。 PBIT，在体外抑制 JARID1B，IC50 约为 3 μm。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥389 | 有现货 |
|
| 5MG | ￥648 | 有现货 |
|
| 10MG | ￥1037 | 有现货 |
|
| 25MG | ￥2333 | 有现货 |
|
| 50MG | ￥3872 | 有现货 |
|
| 100MG | ￥5581 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PBIT
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PBIT 抑制 JARID1B 组蛋白去甲基酶（IC50 约为 3 μM）。 PBIT 还抑制 JARID1A 和 JARID1C（IC50 分别为 6 μM 和 4.9 μM）。 PBIT 是富含 Jumonji AT 的交互域 1 (JARID1) 酶的特异性抑制剂。 PBIT，在体外抑制 JARID1B，IC50 约为 3 μm。
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产品描述PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes . PBIT, which inhibits JARID1B with an IC50 of about 3 μm in vitro.?Consistent with this, PBIT treatment inhibited removal of H3K4me3 by JARID1B in cells.?Furthermore, this compound inhibited proliferation of cells expressing higher levels of JARID1B.?
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体外实验Cell Proliferation Assay Cell Line:Human breast cancer cell lines (UACC-812 and MCF7) and human mammary epithelial cells (MCF10A)Concentration:1, 3, and 10 μM for UACC-812 cells; 2.5, 5, and 10 μM for MCF7 and MCF10A cells Incubation Time:72 hours Result:Inhibited cell proliferation in a JARID1B level-dependent manner. 10 μM killed most of the UACC-812 cells, but showed minimal toxicity to MCF7 cells and MCF10A cells.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体JARID1B|JARID1A|JARID1C
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研究领域——
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适应症——
化学信息
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CAS Number2514-30-9
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分子量241.31
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分子式C14H11NOS
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (414.40 mM; Need ultrasonic)
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SMILESO=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.
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