PAT-1251 ( PAT 1251;PAT1251 )

产品货号. M13132 CAS No. 2007885-39-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PAT-1251
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PAT-1251 (PAT 1251, PAT1251) is apotent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays.
产品描述

PAT-1251 (PAT 1251, PAT1251) is apotent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases; exhibits efficacy in mouse bleomycin lung fibrosis model.Fibrosis Phase 1 Clinical
同义词

PAT 1251;PAT1251
通路

Others
靶点

Other Targets
受体

Other Targets
研究领域

Other Indications
适应症

Fibrosis

CAS Number

2007885-39-2
分子量

399.35
分子式

C18H17F4N3O3
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 130 mg/mL 325.54 mM
SMILES

O=C(C1=CC=CC(OC2=NC(C(F)(F)F)=CC(CN)=C2)=C1)N3C[C@@H](F)[C@H](O)C3
化学全称

(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone

1. Rowbottom MW, et al. J Med Chem. 2017 May 25;60(10):4403-4423.

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