
P7C3
CAS No. 301353-96-8
P7C3 ( P7C3 )
产品货号. M13940 CAS No. 301353-96-8
P7C3 类神经保护性氨基丙基咔唑已被证明可以阻止神经变性模型中的神经元细胞死亡。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥348 | 有现货 |
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10MG | ¥567 | 有现货 |
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25MG | ¥1077 | 有现货 |
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50MG | ¥1936 | 有现货 |
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100MG | ¥3216 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称P7C3
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述P7C3 类神经保护性氨基丙基咔唑已被证明可以阻止神经变性模型中的神经元细胞死亡。
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产品描述The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage.
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体外实验Western Blot Analysis Cell Line:BV2 cells Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:2 hours Result:Reduced the protein levels of iNOS, COX-2.
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体内实验Animal Model:6-8 weeks male C57BL/6 mice (25-30 g)Dosage:20 mg/kg/d Administration:Intraperitoneal injection, twice daily, for 21 days Result:Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc).
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同义词P7C3
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通路Others
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靶点Other Targets
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受体nicotinamide phosphoribosyltransferase
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number301353-96-8
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分子量474.19
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分子式C21H18Br2N2O
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纯度>98% (HPLC)
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溶解度Soluble in DMSO
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SMILESOC(CNC1=CC=CC=C1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
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化学全称1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Yin TC, et al. Cell Rep. 2014 Sep 25;8(6): 1731-40.
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