P7C3-A20

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

P7C3 是一种与拉替吡啶 (dimebon) 相关的化合物，具有神经保护和促神经生成作用，可能可用于治疗阿尔茨海默病和类似的神经退行性疾病。

P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.

Cell Viability Assay Cell Line:PC12 cells Concentration:10?μM, 20 μM, 40?μM, 60 μM, 80?μM, 100 μM Incubation Time:8 hours Result:Alleviated oxygen-glucose deprivation (OGD)-induced cytotoxicity in PC12 cells. Apoptosis Analysis Cell Line:PC12 cells Concentration:40?μM, 60 μM, 80?μM, 100 μM Incubation Time:8 hours Result:Alleviated oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells.

Animal Model:Sprague-Dawley rats (200-250 g) induced hypoxic-ischemic (HI) injury Dosage:5?mg/kg, 10?mg/kg Administration:Intraperitoneal injection; daily; for 7 days Result:Reduced infarct volume; reversed cell loss in the cortex and hippocampus and improved motor function without causing neurotoxicity.

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Tyrosine Kinase

Src

Others

Neurological Disease

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1235481-90-9

506.2

C22H19Br2FN2O

>98% (HPLC)

DMSO : ≥ 100 mg/mL. 197.55 mM; H2O : < 0.1 mg/mL

COc1cccc(c1)NCC(Cn1c2c(cc(cc2)Br)c2c1ccc(c2)Br)F

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(-20℃)

With Ice Pack

≥ 2 years