P005091
CAS No. 882257-11-6
P005091 ( P005091; P-005091; P 005091;P 5091 )
产品货号. M19224 CAS No. 882257-11-6
P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥316 | 有现货 |
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5MG | ¥510 | 有现货 |
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10MG | ¥656 | 有现货 |
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25MG | ¥1280 | 有现货 |
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50MG | ¥2187 | 有现货 |
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100MG | ¥3499 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称P005091
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
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产品描述P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μ M). P005091 induces elevated p53 and apoptosis in cancer cell lines and displays antiangiogenic activity in vivo . The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention.
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同义词P005091; P-005091; P 005091;P 5091
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通路Others
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靶点Other Targets
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受体USP7
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研究领域Cancer
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适应症——
化学信息
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CAS Number882257-11-6
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分子量348.21
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分子式C12H7Cl2NO3S2
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纯度98%
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溶解度DMSO : 50 mg/mL 143.59 mM; H2O : < 0.1 mg/mL
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SMILESCC(=O)c1cc(c(Sc2cccc(Cl)c2Cl)s1)[N+](=O)[O-]
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化学全称1-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethanone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Chauhan D, et al. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell. 2012 Sep 11;22(3):345-58.
产品手册
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