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P-1075
CAS No. 60559-98-0
P-1075 ( —— )
产品货号. M26779 CAS No. 60559-98-0
P-1075 是一种有效的磺酰脲受体 2 相关 ATP 敏感钾通道 (SUR2-KIR6) 激活剂 (EC50 = 45 nM)。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥648 | 有现货 |
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5MG | ¥1037 | 有现货 |
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10MG | ¥1725 | 有现货 |
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25MG | ¥3183 | 有现货 |
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50MG | ¥4771 | 有现货 |
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100MG | ¥6828 | 有现货 |
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500MG | ¥14013 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称P-1075
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述P-1075 是一种有效的磺酰脲受体 2 相关 ATP 敏感钾通道 (SUR2-KIR6) 激活剂 (EC50 = 45 nM)。
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产品描述P-1075 is a potent sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6) activator (EC50 = 45 nM). P-1075 opens opens mitoKATP channels and may be cardioprotective.
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体外实验P1075 (3 nM) induces monophasic inhibition curves by competition-binding experiments, in the presence of MgATP.P1075 (100 μM; 10 min) leads to rabbit cardiomyocytes to produce ROS in a KATP-dependent fashion.P1075 (150 nM) reduces infarct size in isolated rabbit hearts compared to control animals (10.6% of the area at risk vs. 31.5%, P < 0.05). Cell Viability Assay Cell Line:COS-7 cells Concentration:3-15 nM Incubation Time:Result:Showed IC50 value of 15 nM and Hill coefficient of 1.0.Cell Viability Assay Cell Line:Adult rabbit cardiomyocytes Concentration:100 μM Incubation Time:10 min Result:Led to a 44% increase in ROS generation (P<0.001 vs. untreated cells).
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体内实验P1075 (intravenous injection; 1μg/kg; once) treatment shows the reduction of infarct size in ischemia model. Animal Model:Male Sprague-Dawley rats subjected to 30 minutes of ischemia and 2 hours of reperfusion Dosage:1μg/kg Administration:Intravenous injection; 1μg/kg; once Result:Reduced infarct size (41.8%) compared to the vehicle.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体Human Endogenous Metabolite
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研究领域——
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适应症——
化学信息
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CAS Number60559-98-0
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分子量231.303
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分子式C12H17N5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (1080.85 mM)
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SMILESCCC(C)(C)N\C(NC#N)=N\c1cccnc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Murr C, et al. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism [01 Apr 2002, 3(2):175-187].