Oxythiamine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Oxythiamine (Hydroxythiamin) 是一种抗代谢物的类似物，可以抑制核糖的非氧化合成，诱导细胞凋亡 (apoptosis) 。Oxythiamine 是一种硫胺素拮抗剂，可抑制转酮醇酶 (transketolase) (TK)。Oxythiamine 抑制癌细胞凋亡 (apoptosis) 并抑制细胞增殖。

Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation.

Cell Viability Assay Cell Line:MIA PaCa-2 cells Concentration:0-40 μM Incubation Time:2 days Result:Inhibited cell viability with an IC50 of 14.95 μM.Western Blot Analysis Cell Line:MIA PaCa-2 cells Concentration:0, 5, 50, 500 μM Incubation Time:48 h Result:Inhibited 14-3-3 protein beta/alpha expression, and increased alpha-enolase.

Animal Model:Ehrlich's ascites tumor hosting miceDosage:100-500 mg/kg Administration:i.p., 4 days Result:Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg.

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Others

Other Targets

Transketolase | Apoptosis

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136-16-3

266.34

C12H16N3O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 51.67 mg/mL (194.00 mM; 超声助溶 )

O=C1NC(=NC=C1C[N+]2=CSC(=C2C)CCO)C

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(-20℃)

With Ice Pack

≥ 2 years