
Oxypaeoniflorin
CAS No. 39011-91-1
Oxypaeoniflorin ( —— )
产品货号. M18513 CAS No. 39011-91-1
氧芍药甙是从赤芍和白芍中提取的天然产物。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥648 | 有现货 |
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5MG | ¥1158 | 有现货 |
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10MG | ¥2041 | 有现货 |
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25MG | ¥3669 | 有现货 |
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50MG | ¥5403 | 有现货 |
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100MG | ¥7687 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Oxypaeoniflorin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述氧芍药甙是从赤芍和白芍中提取的天然产物。
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产品描述Oxypaeoniflorin is a natural product derived from Radix Paeoniae Rubra and Radix Paeoniae Alba.
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体外实验Oxypaeoniflorin (OPA; 0.1-10 μM; 8 hours) obviously reversed the hypoxia/reoxygenation (H/R)-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Oxypaeoniflorin inhibits apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells. Oxypaeoniflorin (0-30 μM) attenuates inflammatory effects via regulation of the toll-like receptor (TLR), extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases signaling pathways in LPS-stimulated RAW264.7 cells.
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体内实验Oxypaeoniflorin (OPA; 10-40 mg/kg; intragastrical administration; every day; for 30 days) treatment significantly reduces disruption of cardiac function and improves the indicators of ejection fraction (EF) and fractional shortening (FS). Oxypaeoniflorin significantly reduces the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT). Animal Model: C57BL/6 male mice (6-8 weeks of age, 20-25 g) bearing myocardial ischemia/reperfusion (MI/R) injury Dosage:10 mg/kg, 20 mg/kg, 40 mg/kg Administration:Intragastrical administration; every day; for 30 days Result:Significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS).
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域Others-Field
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适应症——
化学信息
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CAS Number39011-91-1
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分子量496.46
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分子式C23H28O12
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纯度>98% (HPLC)
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溶解度DMSO : 100 mg/mL 201.43 mM
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SMILESC[C@]12C[C@@]3([C@@H]4C[C@]1([C@@]4([C@H](O2)O3)COC(=O)c1ccc(cc1)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. M. Kaneda, Tetrahedron Volume 28, Issue 16, 1972, Pages 4309-4317
产品手册




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