Opipramol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Opipramol (Ensidon) 是一种非典型的三环类抗抑郁试剂 (TCA)。Opipramol 主要用作 sigma (σ) 受体激动剂，可以有效地与 sigma 识别位点相互作用，Ki 值为 50 nM。Opipramol 可用于广泛性焦虑症（GAD）的研究。

Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD).

Opipramol can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol inhibit the uptake of [3H] DA in crude synaptosomal preparations with an IC50 value of 5.5 μM.

Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo.Animal Model:Sprague-Dawley rats (male, 150-l 80 g) Dosage:5-50 mg/kg Administration:Intraperitoneal injections Result:Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA.Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat.Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose.

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Autophagy

Sigma receptor

Sigma receptor

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315-72-0

363.5

C23H29N3O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (275.10 mM; 超声助溶 )

OCCN1CCN(CC1)CCCN2C=3C=CC=CC3C=CC=4C=CC=CC42

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(-20℃)

With Ice Pack

≥ 2 years