Oglemilast ( GRC 3886 )

产品货号. M15938 CAS No. 778576-62-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Oglemilast
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.
产品描述

Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.Asthma Phase 1 Discontinued
同义词

GRC 3886
通路

Angiogenesis
靶点

PDE
受体

PDE
研究领域

Inflammation/Immunology
适应症

Asthma

CAS Number

778576-62-8
分子量

516.30
分子式

C20H13Cl2F2N3O5S
纯度

>98% (HPLC)
溶解度

DMSO : 4 mg/mL7.75 mM;H2O : < 0.1 mg/mL
SMILES

O=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl
化学全称

N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide

1. Giembycz MA. Br J Pharmacol. 2008 Oct;155(3):288-90.

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