OXFBD04

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

OXFBD04 是一种有效的、选择性的 BRD4 抑制剂（IC50 为 166 nM）。

OXFBD04 is a potent and selective inhibitor of BRD4(IC50 of 166 nM).(In Vitro):OXFBD04 (0.01-100 μM) inhibits the cell growth of cancer cell lines. In MCF7 breast cancer cells, OXFBD04 (10?μM) induces MYC suppression.(In Vivo):OXFBD04 has optimized physicochemical properties (LE = 0.43; LLE = 5.74; SFI = 5.96), and greater metabolic stability (t1/2 = 388?min, CLint = 3.57 μL/min/mg).

OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth. OXFBD04 (10?μM; for 10, 24, or 48?hours) induces MYC suppression in MCF7 breast cancer cells. Cell Viability AssayCell Line:A498 (renal), HT-29 (colon), and MCF7 (breast) cancer cell lines Concentration:0.01, 0.1, 1, 10, 100 μM Incubation Time:48 hoursResult:Inhibited cancer cell lines growth.

OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t1/2=388?min). OXFBD04 has CLint of 3.57 μL/min/mg.

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Chromatin/Epigenetic

Epigenetic Reader Domain

Anti-infection| Antibacterial| Antibiotic| α-glucosidase

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2231747-03-6

296.326

C17H16N2O3

>98% (HPLC)

In Vitro:?DMSO : ≥ 250 mg/mL (843.68 mM)

Cc1noc(C)c1-c1cc(O)cc(c1)C(O)c1cccnc1

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(-20℃)

With Ice Pack

≥ 2 years