OSBPL7-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

OSBPL7-IN-1 是一种口服活性的氧甾醇结合蛋白类似 7 (OSBPL7) 抑制剂。 OSBPL7-IN-1 促进质膜上 ABCA1 的增加，而不影响 mRNA 表达。

OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression.(In Vitro):OSBPL7-IN-1 (compound G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux.(In Vivo):OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria, and prevents renal function decline in mouse models of proteinuric kidney disease.

OSBPL7-IN-1 (compound G or Cpd G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux.

OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease. Animal Model:Female Balb/c mice induced by Adriamycin (ADR)Dosage:100?mg/kg.Administration:Oral gavage; daily; for 28 days Result:Normalized proteinuria, and significantly reduced renal fibrosis and renal functional decline.

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Other Targets

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1269826-44-9

463.28

C20H19Cl2F3N2O3

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (269.82 mM)

O[C@H](CCCC1)[C@@H]1NC(c(cn1)cc(-c(cc2)cc(Cl)c2Cl)c1OCC(F)(F)F)=O

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(-20℃)

With Ice Pack

≥ 2 years